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Chemical & Biological Processing

Beth Hofstad

Beth Hofstad

Pacific Northwest National Laboratory
PO Box 999
Richland, WA 99352


Beth Hofstad has over 20 years of research experience. Subject areas include fungal biochemical applications, bioremediation, pharmaceuticals, enzyme, organic acid and ethanol production. She currently works in Chemical and Biological Process Development group. Within this group, she is focused on managing projects where the focus is creating biofuels and bioproducts using fungal strains. She is currently working with fellow scientists identifying and quantifying cellulose degrading enzymes using activity based chemical probes. She is assisting in research using proteomics to identify proteins involved in the production of lipids in algae.

She has been part of many publications, including journal articles, conference proceedings and technical reports. Mrs. Hofstad originally joined PNNL in 1990 and rejoined PNNL in 1997 after college.

Research Interests

  • Fundamental research using filamentous fungi to convert biomass to high-value chemical products like fuels, chemicals and enzymes
  • Biochemical process engineering and genetic engineering to better understand and control fungal metabolism

Education and Credentials

  • B.S., Microbiology, Washington State University
  • Project Management Development Program completed, June 2019

PNNL Publications


  • Collett J.R., J.M. Billing, P.A. Meyer, A.J. Schmidt, A.B. Remington, E. Hawley, and B.A. Hofstad, et al. 2019. "Renewable diesel via hydrothermal liquefaction of oleaginous yeast and residual lignin from bioconversion of corn stover." Applied Energy 233. PNNL-SA-133222. doi:10.1016/j.apenergy.2018.09.115
  • Pomraning K.R., J.R. Collett, J. Kim, E.A. Panisko, D.E. Culley, Z. Dai, and S. Deng, et al. 2019. "Transcriptomic analysis of the oleaginous yeast Lipomyces starkeyi during lipid accumulation on enzymatically treated corn stover hydrolysate." BMC Biotechnology for Biofuels 12. PNNL-SA-142743. doi:10.1186/s13068-019-1510-z


  • Bartholomew R.A., R.M. Ozanich, J.S. Arce, H.E. Engelmann, A. Heredia-Langner, B.A. Hofstad, and J.R. Hutchison, et al. 2017. "Evaluation of Immunoassays and General Biological Indicator Tests for Field Screening of Bacillus anthracis and Ricin." Health Security 15, no. 1:81-96. PNNL-SA-116267. doi:10.1089/hs.2016.0044


  • Anderson L.N., D.E. Culley, B.A. Hofstad, L.M. Chauvigne-Hines, E.M. Zink, S.O. Purvine, and R.D. Smith, et al. 2013. "Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30." Molecular Biosystems 9, no. 12:2992-3000. PNNL-SA-97265. doi:10.1039/c3mb70333a
  • Wiedner S.D., C. Ansong, B.M. Webb-Robertson, L.M. Pederson, S. Fortuin, B.A. Hofstad, and A.K. Shukla, et al. 2013. "Disparate Proteome Responses of Pathogenic and Non-pathogenic Aspergilli to Human Serum Measured by Activity-Based Protein Profiling (ABPP)." Molecular & Cellular Proteomics. MCP 12, no. 7:1791-1805. PNNL-SA-91969. doi:10.1074/mcp.M112.026534


  • Chauvigne-Hines L.M., L.N. Anderson, H.M. Weaver, J.N. Brown, P.K. Koech, C.D. Nicora, and B.A. Hofstad, et al. 2012. "Suite of Activity-Based Probes for Cellulose-Degrading Enzymes." Journal of the American Chemical Society 134, no. 50:20521-20532. PNNL-SA-91066. doi:10.1021/ja309790w

Chemical & Biological Processing

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